Neuroendocrinology and Behaviour
Advance Techniques in Neuroscience
Professional ethics and research
Nervous system assembly is orchestrated by a balance between progressive and regressive events. Progressive events include neuron generation and survival, synapse formation, axon growth etc. while the regressive events comprise neuron death, synapse restriction and axon degeneration.
During normal nervous system development neurons are produced in redundant numbers. As the development proceeds, approximately half the number of neurons undergo death leaving behind only the appropriate numbers which are integrated in the neural circuits for efficient functioning of the nervous system. The excessive neuron death is reported in several neurodevelopmental disorders and neurodegenerative diseases like Down’s syndrome, Familial dysautonomia, Amyotrophic Lateral Sclerosis (ALS), Parkinson’s and Alzheimer’s disease.
Our research group is interested in understanding the cellular and molecular mechanism of neuron death during normal nervous system development, neurodevelopmental disorders and neurodegenerative diseases. Specifically, how the death signals are transported from one end of the neuron to their cell body. To investigate the mechanism of death signal
transport, we work with primary neurons cultured in microfluidic devices and rodents in vivo. In addition to classical cell and molecular biology tools, we analyse the neurons in vitro and in vivo by advanced microscopy.
Cellular and molecular neuroscience
Amity Institute of Neuropsychology and Neurosciences (AINN)
J1 Block, Room No. 222A