Clinical resistance to Antifungal Mechanism
Regulation of resistances new Antifungal molecular mycology.
Publications:
1. Yeast ATP-Binding Cassette Transporters Conferring Multidrug Resistance, Prasad R and Andre Goffeau Annual reviews of Microbiology,66,39-63(2012)
2. Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans,Indresh Kumar Maurya,Chaitanya Kumar Thota,Sachin Dev Verma,Jyotsna Sharma,Manpreet Kaur Rawal,Balaguru Ravikumar,Shoban Sen,Neeraj Chauhan,Andrew M. Lynn4, Virander Singh Chauhan and Prasad R Journal of Biological Chemistry JBC Paper of the week, 288, 16775–16787 (2013).
3. Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains. Manpreet Kaur Rawal, Mohammad Firoz Khan, Khyati Kapoor, Neha Goyal, Sobhan Sen, Ajay Kumar Saxena, Andrew M. Lynn, Joel D. A. Tyndall, Brian C. Monk, Richard D. Cannon, Sneha Sudha Komath, and Prasad R J Biol Chem. 288:24480-93 (2013)
4. Mutational Analysis of Intracellular Loops Identify Cross Talk with Nucleotide Binding Domains of Yeast ABC Transporter Cdr1p. Abdul Haseeb Shah, Manpreet Kaur Rawal, Sanjiveeni Dhamgaye, Sneha Sudha Komath, Ajay Kumar Saxena, and Prasad R.,Science Reports,5,11211. (2015)
5. The ABCs of Candida albicans multidrug transporter Cdr1,Prasad R, Banerjee A, Khandelwal NK, Dhamgaye S. Eukaryotic Cell. 14,(12):1154-1164,(2015).
6. Azole resistance in a Candida albicans mutant lacking the ABC transporter CDR6/ROA1 depends on TOR signaling ; Khandelwal NK, Chauhan N, Sarkar P, Esquivel BD, Coccetti P, Singh A, Coste AT, Gupta M, Sanglard D, White TC, Chauvel M, d'Enfert C, Chattopadhyay A, Gaur NA, Mondal AK, Rajendra Prasad.; J Biol Chem. Jan 12;293(2):412-432. (2018) Cover page
7. Molecular basis of substrate polyspecificity of the Candid albicans Mdr1p multidrug/H+ antiporter. Archana K Redhu; Atanu Banerjee, Abdul H Shah; Alexis Moreno, Manpreet K Rawal,Remya Nair,Pierre Falson, Prasad R. J Mol Biol 430(5):682-694, (2018)
8. Vacuolar sequestration of azoles: A novel strategy of azole antifungal resistance conserved across pathogenic and non-pathogenic yeast. Khandelwal Nitesh,Wasi Mohd,Nair, Remya,Gupta Meghna, Mondal Alok Gaur Naseem, Prasad R. Antimicrobial Agent and Chemotherapy doi:10.1128/aac.(63) 01347-18 (2019).
9. Inventory of ABC proteins and their putative role in salt and drug tolerance in Debaryomyces hansenii. Prasad R,Mohd,Wasi,Nitesh K, Khandelwal,Poonam Vishwakarma,Andrew M Lynn, Alok K Mondal. Fungal Genetics and Biology. 15;676:227-242. doi: 10.1016/j.gene.2018.07.029. (2018) .
10. Phosphatidylserine decarboxylase governs plasma membrane fluidity and impacts drug susceptibilities of Candida albicans cells. Prasad R, Nitesh K Khandelwal, Parijat Sarkar, Naseem A Gaur, Amitabha Chattopadhyay. BBA – Biomembranes. S0005-2736(18)30158-5 (2018).