16 Dec 2016-|Gurgaon (Manesar) | Amity university Gurgaon
Guest Lecture on Phase Specific Neuroprotective Efficacy of Curcumin in Drosophila Model of Parkinson’s Disease: Therapeutic Implications
Amity Institute of Biotechnology Organized Guest Lecture onPhase Specific Neuroprotective Efficacy of Curcumin in Drosophila Model of Parkinson’s Disease: Therapeutic Implications by Dr. Sarat Chandra Yenisetti Associate Professor Ph.D. PDF(NIH,US and University Regensburg,Germany) on 16th December 2016.
In his Talk he emphasized on efficacy of Curcumin in drosphila Curcumin has been used for centuries in traditional medicines in India and other parts of Asia and has been associated with antioxidant, anti-inflammatory, anticancer, antiviral and antibacterial activities as indicated by over 8000 citations. In addition, over one hundred clinical studies have been carried out with curcumin. Genotropic drugs would be effective only during those life cycle stages during which their target molecules are available. Hence there exists a possibility that targets of genotropic compounds such as curcumin may not be present in all life stages. However no reports are available in Parkinson’s disease (PD) models illustrating efficacy of curcumin in later phases of adult life which is important as this is the period when late onset disorder such as idiopathic PD set in.
To understand this paradigm tested the protective efficacy of curcumin in different growth stages (early, late health stage and transition phase) in adult Drosophila flies and results showed that it can rescue the motor defects during early stages of life but ineffective at later phases. This observation was substantiated with the finding that curcumin treatment could replenish depleted brain dopamine levels in PD model only during early stages of life cycle, clearly suggesting limitation of curcumin as a therapeutic agent in late onset neurodegenerative disorders such as PD.
Overall it was an very informative session for all.