Vision
Creating high quality innovative research and education in interdisciplinary science in synthetic biology, genome engineering and gene editing, for better understanding and management of plant and human health and nutrition. Developing specialized manpower in advanced technologies in genome-engineering to facilitate novel
Read More>
innovations and discoveries in agriculture and human health and diseases thus contributing to the benefit of humankind and the society at large.
Mission
Our mission is to utilize revolutionary genome-editing technology and genome engineering for betterment of humankind. We aim to develop solutions for better health and nutrition through:
Read More>- Developing a multidisciplinary knowledge Centre to provide high quality research, teaching and learning in genome engineering.
- Disseminating value education and training to a new generation of young minds in the frontier areas of synthetic biology and genome engineering.
- Creating a passion for innovative research while imbibing scientific temperament, commitment, sincerity and inquisitiveness for knowledge for betterment of human health/food security through basic and translational research, innovation and education.
- Establishing national and international collaborative networks to promote Amity as an International hub for centre of excellence in research and innovation.
AMITY INSTITUTE OF GENOME ENGINEERING (AIGE)
AIGE is the brainchild of Dr. Ashok K. Chauhan, Hon’ble Founder president of Amity Education Group. He realized immense potential and importance of genome engineering in diverse areas ranging from human health to agriculture. After consulting with many scientific leaders working in this field, he decided to establish this new institute which will be engaged in cutting edge research and innovation in genome engineering for the betterment of humankind.
The institute aims to address the greatest challenges of humankind involving human and plant health and disease, food security, reliable diagnostics, therapeutics including vaccines through utilizing the potentials of most advanced synthetic biology, genome engineering and gene editing technologies. The AIGE scientists have extensive expertise in different areas of genome research. They are involved in conducting high quality research aiming to address challenges for human health, nutrition and many more.
“During the last 10 years, there have been remarkable advancement in genome engineering and gene editing technology. Since the discovery of this most exciting CRISPR-Cas9 method of genome editing, it is anticipated that in near future this approach can be immensely useful for humankind. Scientists are already using it for the cure of diseases like cancer including genetic disorders. At the same time, this approach is also used to develop better crop varieties to provide food resources for our growing population. Considering the huge potential of application of genome engineering, we have established a dedicated Institute of Genome Engineering where concerted interdisciplinary research in this area will be performed for the benefit of humankind and the society at large”.
- Dr. Ashok K Chauhan
Dr. Ashok K Chauhan
Founder President
Dr. Atul Chauhan
Chancellor, Amity University Uttar Pradesh
"At Amity, we are committed to adopt, adapt and imbibe technology driven through innovation for better future. It is evident that genome engineering technology has immense potential to address many complicated and unresolved problems of human health as well as agriculture. Therefore, this new institute AIGE will be devoted to conduct research and education utilizing the advanced genome engineering tools". - Dr. Atul Chauhan
"We are witnessing a revolution in genome engineering technology, and it is important to quickly train our young minds with this modern skill sets to prepare leaders for next generation in this area. Considering this we have established a new institute AIGE which will be engaged in advanced innovative research in genome engineering, synthetic biology and gene editing as well as educate and train students for the betterment of human health, diseases and food security". - Prof. Balvinder Shukla
Prof. Balvinder Shukla
Vice Chancellor, Amity University Uttar Pradesh
From Chairman’s Desk
Prof. (Dr.) Bhudev C. Das, Chairman & Hargobind Khorana Chair Professor
M. Sc., PhD, FNASc, FASc, FAMS, FNA & formerly J.C. Bose National Fellow.
Specialization: Molecular oncology, epidemiology of Cervical Cancer, HPV, transcriptional regulation, cancer genomics chemotherapeutics, stem cell & cancer stem cell therapy and cancer drug discovery Read More
As, the global genome editing market of approximately USD 3.5 billion is expected to expand more and more due to implementation of CRISPR genome editing technology in several biotechnology domains including diagnostics as well as agriculture, there is an urgent need for trained manpower with knowledge and expertise to conduct research and innovation using genome engineering and synthetic biology tools which have excellent scope for a successful career in this domain.
However, in India the research using genome editing tools is still in infancy and realizing this Amity University has pioneered to establish a new Amity Institute of Genome Engineering. The institute will be engaged in different aspects of plant and animal genome research using genome engineering tools and focus on agriculture and diseases including dreaded diseases such as cancer.
Dr. Bhudev C. Das was Founder Director of Institute of Cytology and Preventive Oncology (now NICPR) of ICMR, Noida till 2008 and later he joined as Dr. Gurbaksh Singh Chair Professor and Director of ACBR, Delhi University. Dr. Das has done his Ph.D from Banaras Hindu University, Varanasi and has worked several years with the Nobel Laureate, Prof.(Dr.) Harald ZurHausen at German Cancer Research Centre (DKFZ), Heidelberg, Germany. He has made outstanding contributions in the field of Cancer Research, Human Genetics and Tumor Virology. During the last 46 years of his distinguished research career, he has published more than 215 research papers in reputed international journals that include Nature, Lancet, Nucleic acid research, Oncogene, J. Virology, Hepatology, Molecular Medicine, Human Genetics, Clinical Cancer Research, Scientific Reports, etc. and distinguished himself as a renowned molecular oncologist. In India, Dr. Das has pioneered the work on Human Papillomavirus (HPV) that causes cervical and other cancers and his laboratory was the HPV Referral Centre of WHO for whole of South-East Asia. So far 36 Ph.D and 79 MD/MS/DNB/DM students have received their degrees under his supervision and guidance.
Since discovery of the structure of the DNA by Watson and Crick in 1953 and decoding the function of Genetics code by Hargobind Khorana (1968), there has been challenging quest to explore the structure and function of the genes. With the advancement of molecular techniques and the whole genome sequencing of different organisms, genetic manipulations etc. have become routine in the laboratories. However, genome engineering involving addition or deletion of nucleotides to alter a gene or protein at whole genome level has not been possible until recently. Many genome engineering technologies have recently emerged, namely zinc-finger nucleases (ZFNs), transcription activator–like effector nucleases (TALENs) and RNA-guided CRISPR-Cas nuclease system. The ability to modify and engineer biological systems has immense potential for applications in different areas including human health and agriculture which has been recognized by Nobel foundation in 2020 while giving the Nobel Prize in Chemistry to Emmanuelle Charpentier and Jennifer A. Doudna for their discovery of genome editing technology. This tool has contributed to numerous important discoveries in basic and applied sciences in human and plant. It has been possible to develop crops that withstand mould, pests and drought and the dream of being able to cure inherited human diseases is coming true.
Honours and awards:
- Elected Fellow of all national science and medical academies (FNASc, FASc, FNA and FAMS) Read More>
- Sandoz oration Award for Cancer Research, ICMR, 1992
- Fellow of International Union against cancer (UICC), Geneva since 1996
- Dr. B.C. Ray National Award of Medical Council of India, 1998
- Ranbaxy Medical Research Award, 2005
- WHO expert advisor of the Global HPV Vaccine & LabNet Program
- Elected President, Indian Association for Cancer Research (IACR) (2006-2009)
- Dr. Prem Nath Wahi Award of ICMR in Preventive Oncology for 2006
- J.C. Bose National Fellow of DST since 2008
- FICCI Award for innovative R&D in Life Sciences/Applied Research for 2008/09
- American Asian Scientists (SAASCR) Award in Cancer Research, 2010
Ongoing Research Project:
- ICMR project on “Development of Novel Curcumin-Folate-Drug Conjugates for Targeted delivery of Drug and Curcumin together to Cancer and Cancer Stem Cells for Effective Treatment” Read More>
- DST-BRICS Project on “Identification of key genetic/epigenetic marker(s) in cervical carcinogenesis and development of corresponding molecular therapeutics for precision medicine of cervical cancer”
- ICMR Project on “Analysis of key gene mutations and miRNA's and their interaction with Fos-related antigen 1/2(Fra 1/2) to identify therapeutic target(s) in triple negative breast cancer stem cells”
Selected Recent Publications:
- Aftab, M., Poojary, S.S., Seshan, V. et al. Urine miRNA signature as a potential non-invasive diagnostic and prognostic biomarker in cervical cancer. Scientific Reports 11, 10323 (2021). (IF= 4.379) Read More>
- Ankan M Das, Bhudev C. Das Exposure to endocrine-disrupting chemicals in utero and thyroid cancer risk in offspring. The Lancet Diabetes & Endocrinology 9 (5), 255 (2021) (IF= 32.06)
- Asiya Khan, Bhudev C. Das, Umme Abiha, Sandeep Sisodiya, Atul Chikara, Sheeraz Un Nazir, Ankan M. Das, Alexandre Gomes Rodrigues, Ajit Kumar Passari, Pranay Tanwar, Showket Hussain, Sabia Rashid, Shazia Rashid,Insights into the role of complement regulatory proteins in HPV mediated cervical carcinogenesis, Seminars in Cancer Biology, 2021, (IF= 15.70)
- Abhishek Tyagi, Kanchan Vishnoi, Sutapa Mahata, Gaurav Verma, Shashank Masaldan, Alok C. Bharti, Bhudev C. Das. (2016) Cervical Cancer stem cell selectively overexpress HPV E6 oncoprotein that control stemness and self renewal through upregulation of HES1, Clinical Cancer Research, 22 (16), 4170-84. (IF= 12.53)
- Shilpi Gupta, Prabhat Kumar, Harsimrut Kaur, Nishi Sharma, Daman Saluja, Alok C. Bharti and Bhudev C. Das. (2015) Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Scientific Reports, 5, 16811. (IF= 5.6)
- Anoop Kumar, Showket Hussain, Gagan Sharma, Lutz Gissmann, Bhudev C Das and Mausumi Bharadwaj. (2015) Identification and validation of immunogenic potential of India specific HPV-16 variant constructs: In-silico & in-vivo insight to vaccine development. Scientific Reports, 5, 15751. (IF= 5.6)
Faculty
Dr. Manoj Kumar, Professor
Qualifications: M.Sc., PhD
Specialization: Plant molecular Biology, Cell biology, Abiotic stress, Genome engineering, plant epigenetics, genomics and big data analysis
Email: mkumar18@amity.edu
Read More>
Dr. Ramesha Thimmappa, Ramalingaswami Fellow & Associate Professor
Qualifications: M.Sc., PhD
Specialization: Plant specialized metabolism, Enzyme divergent evolution, Metabolic engineering, and Protein engineering.
Email: rbthimmappa@amity.edu
Read More>
Dr Muhammed Jamsheer K, DST-Inspire Faculty & Assistant Professor - III
Qualifications: M.Sc., PhD
Specialization: Nutrient Sensing and Signaling, Growth Control, Gene Regulation, Genetic Engineering, Molecular Evolution
Email: mjamsheerk@amity.edu
Read More>Infrastructure
State of the art Molecular Biology Laboratory,
Climate controlled Plant growth facility,
Plant tissue culture Facility,
Animal tissue culture facility,
PCR Thermocycler,
Protein biochemistry facility ,
Deep freezer, Freezer etc.
Publications
1.Jamsheer K, Gazara RK, Jindal S, Kumar M(2022). Stepwise origin and evolution of a transcriptional activator and repressor system integrating nutrient signalling in plants. bioRxiv 2022.04.15.488190; doi: https://doi.org/10.1101/2022.04.15.488190 (Under Review in Plant Journal)
2.Ramesha BT et. Al (2022). Innate immunity in sea cucumbers: repurposing sterol biosynthesis for defense. (Accepted Nature Chemical Biology, [IF- 15.04]
3.Romeiro Motta M, Zhao X, Pastuglia M, Belcram K, Roodbarkelari F, Komaki M, Harashima H, Komaki S, Kumar M, Bulankova P, Heese M, Riha K, Bouchez D, Schnittger A (2021). B1-type cyclins control microtubule organization during cell division in Arabidopsis. EMBO Reports Dec 9:e53995. doi: 10.15252/embr.202153995. [IF – 8.8].
4.Jamsheer K, Muhammed, and Kumar, Manoj; (2021) “Transcription factors as zinc sensors in plants”. Trends in Plant Science 2021 Aug;26(8):761-763.) [IF – 18.31].
5.Jamsheer K, Muhammed, Kumar, Manoj; Srivastava, Vibha (2021) SNF1-Related Protein Kinase 1: the many-faced signaling hub regulating developmental plasticity in plants. Journal of experimental Botany Sep 2;72(17):6042-6065. [IF – 6.99].
6.Topno R$; Nazam N$; Kumari P, Kumar M*; Agarwal P*(2021); Integrative genome wide analysis of protein tyrosine phosphatases identifies CDC25C as prognostic and predictive marker for chemoresistance in breast cancer. Cancer Biomarkers July 9, 1-14 (*corresponding Author) [IF- 4.38]
7.Rachel Topno1*, Ibha Singh2*, Manoj Kumar1#, Pallavi Agarwal2# (2021) Integrated bioinformatic analysis identifies UBE2Q1 as a potential prognostic marker for high grade serous ovarian cancer. BMC Cancer Mar 4;21(1):220. (*corresponding Author) [IF- 4.4]
8.Aditi Chauhan, Manoj Kumar, Awanish Kumar, Kajal Kanchan (2021) Comprehensive review on mechanism of action, resistance and evolution of antimycobacterial drugs. Life Sciences Elsevier, [IF: 3.64]
9.Mohan Sharma, Muhammed Jamsheer K., Brihaspati Narayan Shukla, Manvi Sharma, Prakhar Awasthi, Sanjeet Kumar Mahtha, Gitanjali Yadav and Ashverya Laxmi* (October 2021) Arabidopsis Target of Rapamycin Coordinates with Transcriptional and Epigenetic Machinery to Regulate Thermotolerance. Frontiers in Plant Science [IF – 5.75]
10.Mancera-Martínez E, Dong Y, Makarian J, Srour O, Thiébeauld O, Jamsheer K M, Chicher J, Hammann P, Schepetilnikov M, Ryabova LA. Phosphorylation of a reinitiation supporting protein, RISP, determines its function in translation reinitiation. Nucleic Acids Res. 2021 Jul 9;49(12):6908-6924. IF: [16.97]
11.Jamsheer K M, Jindal S, Sharma M, Awasthi P, S S, Sharma M, Mannully CT, Laxmi A. A negative feedback loop of TOR signaling balances growth and stress-response trade-offs in plants. Cell Rep. 2022 Apr 5;39(1):110631. doi: 10.1016/j.celrep.2022.110631. PMID: 35385724. [IF: 9.423]
CONTACT US
Amity Institute of Genome Engineering,
J3-307
Amity University Campus
Sector-125,
Noida-201303
Phone: 0120-4586855
Mobile: 91-8130606394
E-mail: bcdas@amity.edu
Admission Advertisement AIGE
