Amity International School, Mayur Vihar is affiliated to CBSE vide Affiliation No. 2730586. Under this affiliation, the school is running three steams namely Science, Commerce and Humanities at the senior secondary level. Along with compulsory subjects, the school offers a wide range of choice for optional subjects like Economics, Psychology, Legal Studies, Computer Science, Sculpture, Painting, Physical Education, etc.

For efficient and effective functioning of the board, CBSE has set up a number of regional offices in various parts of the country to conduct the examination successfully. AIS Mayur Vihar falls under the jurisdiction of Delhi Region.