|| AMITY INSTITUTE OF BIOTECHNOLOGY, NOIDA ||

RESEARCH

The institution with its strong backup of the infrastructure, specialized laboratories and highly qualified faculties provide cutting-edge knowledge to the students with exposure to varying trends in biotechnology industry. Students after graduation and post graduation have attained high positions and reputations in the institutions of higher learning and also as employee in the country & abroad.

Our students have earned very prestigious Vice Chancellors Scholarship from University of ULSTER, North Ireland, UK for their Ph. D work in two successive years 2005 and 2006. The institution also runs DST, CSIR, Ministry of Health & Welfare, sponsored research projects in highly specialized area of Biotechnology and Bioinformatics, in the national thrust area. Some of these projects cover the following titles:

Plant desired compound as inhibitors of elongating Mannosyl Phosphate Transfrase an enzyme which is responsible for assembly of cell surface phosphoglycans of Leismania parasites to develop control measures for Kalazar etc.

Synthesis of novel heterocycles of biological interest using 1, 3 dipolar cycloaddition reactions – which would create molecules for breast cancer.

In vitro production of psoralin from Psoralea corylifolia L. an important bioactive compound.

Health & family welfare infrastructure (Public & Private) in east khasi hills (Meghalaya) focusing on abortions.

Conformational studies and structure-f relationship of a tissue plasminogen activator.

Structural and functional properties of tissue plasminigen activator and understanding the factors responsible for its stability.

One of the faculty has left for Berlin, Germany to work with the research group on molecular modeling in collaboration with German counter part in Berlin.

Faculty has published research papers in the national and international journals.

Expert/Technical Services

The Institute is offering expert/technical services to sister institutions of Amity in the areas of Home Grown Technologies viz. low cost bio-fertilizer based organic culture, mushroom production (both oyster and button), maintenance of eco-friendly bio-cultures, intensive propagation of Jatropha carcus as a source of bio-diesel

Training Programmes

The Institute has been identified as a centre for training B.Tech Biotechnology students by the Ministry of Human Resource Development, Govt. of India, and several students are being assigned to carry out small projects for a month. Some Post-Graduate students have already undergone 3-month training on various projects at this Institute and the programme is continuing and becoming popular attracting students from different parts of the country south India.

Following research projects have been approved by different government funding agencies :

Principal Investigator and Project Title

Dr. Sabri Ghosal

Plant derived compounds as inhibitors of elongating MPT, a key enzyme responsible for cell surface phosphoglycans of Leishmania parasites.

Dr. Shoma Paul Nandi

Identification and partial purification of medicinal plant extract effective against Helicobacter pylori.

Dr. Seema Bhatnagar

Synthesis of novel heterocycles of biological intrest using 1,3 dipolar cycloaddition reactions.

Dr. Shakti Sahi

Nonmammalian Eicosanoids, Bioactive Lipids and Plant Oxylipins.

Dr. Roumi Dev

Health and family welfare infrastructure (public and private) in east khasi hill (Meghalaya) focusing on abortion.

Dr. Sahnaz Subhan

In Vitro production of psoralen- an important bioactive compound through cotyledon culture of an endangered legumious taxon Psoralea corylifolia linn

Dr. Sanjeev Kumar

Transformation for abiotic stress tolerance through Gly I gene in ammi majus for enhancement of xanthotoxin

Projects technically approved

Principal Investigator and Project Title

Dr. A.N. Sahi

Establishing the mechanism of enhanced crop productivity in response to fly ash as soil ameliorant.

Dr. Roumi Deb

Demographic and Genetic Studies related to the incidence of Neural Tube Defects (NTDs)

Projects Submitted

Principal Investigator and Project Title

Dr. Rachana Singh

Non-Conventional use of coal combustion ash in reducing heavy metal toxicity in polluted water/industrial effluents and developing a prototype column for metal removal at a pilot scale (TIFAC, DST)

Dr. Shahnaz Subhan

Development of a microbial recycling of flyash solid waste generated out due to various effluent treatment processes (TIFAC, DST)

Dr. Shakti Sahi

To develop the information system for microbes responsible in biodegradation of heavy metals (TIFAC, DST)

Dr. Kanak Sinha

Purification & characterization of antimicrobial substance – Saponins, from in vivo and in vitro grown Medicago sativa I

Dr. Monendra Grover

Cloning and characterization of a gene coding for a pathogen induced calmodulin binding protein and studies on the regulatory aspects of its expression in banana (Dept. of Biotechnology, DST)

Research Proposals submitted by Amity Institute of Biotechnology to different Funding Agencies are...

S. No	Title of the Project	Principal Investigator (PI)	Submitted to
1	Micropropogation and study of abiotic stress in Tylophora indica – a medicinal plant	Dr. Sanjeev Kumar	DST
2	Micropropogation and study of abiotic stress and secondary metabolite content in Viola odorata, a medicinal plant	Dr. Sanjeev Kumar & Ms. Shalini Jain	TWNSO- ITALY
3	Plant regeneration in maize variety ‘shaktiman’ hybrid 1 &2 under water stress	Dr. Nilima Rao	TWNSO- ITALY
4	A study of socio-economic, nutritional and genetic factors influencing alcoholism in India and Nepal	Dr. Rachana Singh Dr. Rumi Deb	TWNSI-ITALYc.c. : Institute of Agricultural & Animal Science Nepal
5	Health and Family Welfare Infrastructure (Private and Public Sector) in Meghalaya Focusing on Gender Issues.	Dr. Rumi Deb	Ministry of Health and Family Welfare, Department of Family Welfare
6	Micropropagation, abiotic stress and estimation of secondary metabolites in Crataeva nurvala Forst. (syn. C. religiosa Hook.)- a medicinal plant.	Dr. Sanjeev Kumar	Indian Council of Medical Research
7	Socio-economic, Demographic and Genetic Studies related to the incidence of Neural Tube Defects (NTDs)	Dr. Rumi Deb	Indian Council of Medical Research
8	In vitro regeneration, enhancement of secondary metabolite of Ginkgo biloba cultures	Dr. Shahnaz Subhan	Indian Council of Medical Research
9	Genetic and epidemiological investigations of some population groups of Andhra Pradesh	Dr. Rumi Deb in collaboration with Dr.K.N. Saraswati (Delhi University)	Department of Biotechnology
10	Strengthening of infrastructure facilities for micropropagation of selected medicinal plants, isolation, characterization and purification of secondary metabolites and cryopreservation of in vitro propagules	Ritinand Balved Education Foundation	National Horticulture Board
11	Effects of extracts of selected medicinal plants on survival of Leishmania donovani Promastigotes	Dr. Sabri Ghosal	International Foundation For Science
12	In vitro production of psoralin an important bioactive compound through cotyledon culture of an endangered	Dr. Shahnaz Subhan	DST
13	Stem cell Isolation & cryopreservation	Dr. Shruti Shukla	DST
14	Anticancer agents from herbal sources. e.g. Brahmi	Dr. Shruti Shukla Dr. Shahnaz Subhan	DBT
15	Molecular diagnostic markers in Indian breast cancer	Dr. Shruti Shukla	Collaborative : AIB, DBT, AIIMS & ICMR
16	Micropropagation of salt-resistant glycophytes	Dr. Kanak Sinha	DBT
17	Characterization of thermostable enzymes from Actinomycetes	Dr. Santosh Kumar Dr. Kanak Sinha	CSIR
18	Non-Conventional use of coal combustion ash in reducing heavy metal toxicity in polluted water/industrial effluents and developing a prototype column for metal removal at a pilot scale	Dr. Rachana Singh	National Mission Sponsoring agency (TIFAC)
19	Development of a microbial recycling of flyash solid waste generated out due to various effluent treatment processes	Dr. Shahnaz Subhan	TIFAC
20	Establishing the mechanism of enhanced crop productivity in response to Flyash as soil ameliorant. impact assessment of induced chromosomal aberrations in crops	Dr. A.N. Sahi	TIFAC
21	To develop the information system for microbes responsible in biodegradation of heavy metals.	Dr. Shakti Sahi	(Fly Ash)TIFAC
Faculty publications The faculty at AIB has got nearly 92 research papers published in journals of National (43) and International (49) repute between 2000 – 2006. Two Books have been authored by a faculty member.